Original from: Technology Network

Scientists have just slotted into place a big piece of the puzzle that explains how our blood cells mount their first line of defence against viruses. They hope this discovery will help them one day better control the response to either boost it or calm it down as appropriate.

The scientists behind the discovery include Andrew Bowie, Professor of Innate Immunology at Trinity College Dublin, who is based in the Trinity Biomedical Sciences Institute, and Drs Lili Gu and David Casserly (formerly at Trinity as postdoctoral and PhD researchers respectively).

Their findings, which provide a target for new therapies that could improve anti-viral responses in some patients and reduce autoimmune problems in others when immune responses run out of control, have just been published in leading journal Nature Communications. 

Interferons and MNDA – a major piece of the puzzle

“Interferons” are key proteins that tell our immune systems when viruses, germs or cancer cells are in our bodies. Type I interferons are produced when the innate immune system senses the presence of a virus. In such circumstances interferons trigger a complex chain of events in which other cells are kicked into gear to “interfere with” and fight those invaders.

Scientists don’t fully understand how certain links in that chain of events are controlled—making it difficult to stimulate or suppress an immune response with therapeutic interventions—but this new research has provided key new insights into the process.

The scientists have discovered that another protein, myeloid cell nuclear differentiation antigen (MNDA), is needed for Type I interferon production from human blood cells in response to viruses. Their work shows that MNDA regulates a transcription factor, IRF7, which in essence drives Type I interferon production.

Professor Andrew Bowie said: 

“We have been interested in better understanding how Type I interferons are produced from blood cells because they are required to fight viruses, and because too much of them—when the production process runs out of control, for example—contributes to nasty autoimmune diseases such as interferonopathies.

The scientists are currently examining how MNDA contributes to innate immune responses to COVID-19.

Source: How Immune Response Against Viruses Is Driven by Key Protein